The Chitin Lab, a working digital twin of the process
Move a setpoint and watch the design space, the capability index and the quality attributes respond. The co-pilot in the corner can read the live state of this page and reason about it with you.
QTPP, risk, design space and control strategy
The four ICH Q8 artefacts, connected. Change a setpoint in the design space and the capability analysis rebuilds from a Monte Carlo over your stated control noise.
Capability is a 400 run Monte Carlo over the stated pH and temperature control noise. Cpk at or above 1.33 is the usual bar for a validated commercial process.
Kinetics bench
Michaelis-Menten and Lineweaver-Burk for the chitinolytic system, with the inhibition modes that actually limit an industrial hydrolysis.
- Apparent Vmax
- 38.86 U/mL
- Km (set)
- 1.50 % w/v
- kcat/Km index
- 12.99
- Rate at 1.5% substrate
- 19.49 U/mL
Anchored to 38.98 U/mL at 1.5% colloidal chitin, pH 7.0, 44 C (DOI 10.1007/s11356-022-22166-x). Inhibition terms are illustrative.
Classic Michaelis-Menten hyperbola.